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Immune-associated adverse reactions When nivolumab is administered together, confer with the SmPC of the opposite blend therapy agents prior to initiation of remedy. Immune-linked adverse reactions have occurred at greater frequencies when nivolumab was administered in combination with ipilimumab as opposed with nivolumab as monotherapy. Immune-connected adverse reactions have occurred at identical frequencies when OPDIVO was administered in combination with cabozantinib relative to nivolumab monotherapy.
Scarce scenarios of SJS and 10 a number of them with lethal consequence are observed. If signs and symptoms or signs of SJS or TEN seem, remedy with nivolumab or nivolumab together with ipilimumab must be discontinued along with the affected individual referred to your specialised unit for assessment and therapy.
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When OPDIVO is administered together with ipilimumab, if either agent is withheld, the opposite agent also needs to be withheld. If dosing is resumed following a hold off, either the combination treatment or OPDIVO monotherapy could possibly be resumed based on the analysis of the individual individual.
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** nivolumab together with ipilimumab for the initial four doses then followed by nivolumab monotherapy in RCC and dMMR or MSI-H CRC.
For added info on the protection profile of ipilimumab buy opdivo monotherapy, you should confer with the ipilimumab SmPC.
Immune-similar hepatitis Intense hepatitis is observed with nivolumab monotherapy or nivolumab in combination with ipilimumab (see section 4.
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